Serum CA125 level in patients with acute pulmonary thromboembolism

Background and Aims: Carbohydrate antigen 125 (CA125) have been found elevated in many diseases other than ovary carcinoma. This study is to investigate the relationship between CA125 level and severity stratification of acute pulmonary thromboembolism. Methods: A total of 77 patients suffering from acute pulmonary thromboembolism were enrolled into our study. These patients were divided into 3 groups: Group I (low risk group, n=25), Group II (intermediate-low risk group, n=28) and Group III (intermediate-high risk and high risk groups, n=24) according to the classification standard of 2014 ESC Guidelines. Control group was consisted of 38 age-sex matched healthy persons. CA125 level were measured in all subjects. Data were analyzed with Kruskal-Wallis tests, chi-squared tests or one-way ANOVA. Results: The mean level of CA125 in group III (44.6±43.0 U/ml) was significantly higher than that in group II (19.0±11. P<0.05), group I (11.0±4.6. P<0.001) and control group (11.0±3.8. P<0.001). It was also significantly higher in group II than that of group I and control group (P<0.05). BNP and PASP were positively correlated with CA125 (respectively, r=0.574, p<0.001; r=0.390, p=0.006), LVEF were negatively correlated with CA125 (r=-0.102, P=0.009). Conclusions: CA125 level in patients with acute pulmonary thromboembolism might due to the severity of the disease. The serum level of CA125 was positively correlated with the value of BNP and PASP, but negatively correlated with LVEF.